Data/hora: 14/05/2024 00:41:25

Biblioteca(s): 	Embrapa Caprinos e Ovinos.	
Data corrente: 	17/04/1997	
Data da última atualização: 	17/04/1997	
Autoria: 	SAHU, S. N.; MOGHA, I. V.; SHARMA, A. K.	
Título: 	Clinical and histopathological changes following repeated pyelography in normal and nephrectomized goats.	
Ano de publicação: 	1996	
Fonte/Imprenta: 	Indian Journal of Animal Science, v.66, n.11, p.1142-1144, 1996.	
Idioma: 	Inglês	
Conteúdo: 	The repeated intravenous pyelography m is specially required for the diagnosis and therapeutic assessment of chronic urinary b: tract disorders. The functional changes in kidney observed following administration of contrast media are marked and frequent in o patients with pre-existing renal diseases if (Dawson 1985). ln this study, cytotoxic effects of repeated intravenous injection of sodium iothalamate on kidney, ureter, urinary  bladder, heart, Iiver, brain and intestine have been assessed in normal and unilateral nephrectomized goats. Clinical examination included recording of temperature, pulse and respiration. Clinically healthy adult indigenous goats (24) were randomly divided into 4 groups of 6 animals each. Unilateral nephrectomy was performed in 12 animals of groups 2 and 4. ln animaIs of groups 1 and 2, intravenous pyelography (IVP) was done at 3 occasions with an interval of 48 hr. The animals were kept off feed for 24 hr. A compression band was applied at the level of third/fourth lumbar vertebrae followed by intravenous injection of sodium iothalamate 70% @ 2 ml/kg body weight. Radiographs were taken at 5, 10 and 15 min of injection in standing lateral and ventrodorsal positions. The compression band was unticd after 10 min of radiography. The animaIs of different groups did not reveal any significant gross lesions in any of the visceral organs examined.  Microscoplcally, kldney showed mild to moderate degeneration of tubular epithelium in the cortex (Fig. 1) and the presence of intralumenal material (Fig. 2). Killen et al. (1959) reported similar findings. ln this study, however, the changes were more prominent in animaIs of group 2. Thisi indicates that renal changes by sodium iothalamate were relatively more in nephrectomized animaIs. The ureter showed focal thinning and desquamation of epithelium in animals of group 2. Urinary bladder showed areas of epithelial desquamation and sub-epithelial edema (Fig. 3): Hepatocytes showed mild to moderate degenerative changes in animaIs of groups 1 and 2. Other organs did not show any pathological lesions, indicating that sodium iothalamate is mainly nephrotoxic and slightly hepatotoxic effects due to its direct contact with kidney and liver cells. Killen and Lance (1960) reported that the nephrotoxicity is dependent upon the chemical structure of the contrast agents. It is concluded that 3 IVP injections of sodium iothalamate were satisfactory with least deleterious effccts on normal and unilateral nephrectomized goats.	
Palavras-Chave: 	Trato urinario.	
Thesagro: 	Doença; Infecção; Rim.	
Categoria do assunto: 	--	
Registro original: 	Embrapa Caprinos e Ovinos (CNPC)	
Exemplares: 	CNPC - (2624-1) - ADC - AP - -- -  -  - 1997.00000 - DIS